Journal of Sports Science and Medicine
Journal of Sports Science and Medicine
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ISSN: 1303 - 2968   
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©Journal of Sports Science and Medicine (2017) 16, 429 - 437

Research article
Long Term Changes in Muscles around the Knee Joint after ACL Resection in Rats: Comparisons of ACL-Resected, Contralateral and Normal Limb
Mahiro Ohno1, Hiroto Fujiya1, , Katsumasa Goto1,3, Mitsutoshi Kurosaka2, Yuji Ogura2, Kanaka Yatabe1, Takaaki Kudo1, Hajime Kobayashi1, Hisateru Niki4, Haruki Musha1
Author Information
1 Department of Sports Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan
2 Department of Physiology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan
3 Department of Physiology, Graduate School of Health Sciences, Toyohashi SOZO University, Toyohashi, Aichi, Japan
4 Department of Orthopaedic Surgery, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan

Hiroto Fujiya
✉ Department of Sports Medicine, St. Marianna University School of Medicine, Kawasaki, 2-16-1 Sugao, Miyamae, Kawasaki, Kanagawa, 216-8511, Japan
Email: fujiya-1487@marianna-u.ac.jp
Publish Date
Received: 05-06-2017
Accepted: 31-07-2017
Published (online): 08-08-2017
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ABSTRACT

The purpose of this study was to investigate the long-term effects of anterior cruciate ligament (ACL) resection on the morphological and contractile characteristics of rectus femoris (RF) and semimembranosus (SM) muscles in both injured and contralateral hindlimbs in rats. Wistar male rats (8-week old) were used. Rats were divided into two groups; ACL-resected and (sham-operated) control groups. Furthermore, right and left limbs of rats in the ACL-resected group were assigned as ACL-resected and contralateral groups, respectively, at 1 day, 1, 4, and 48 weeks after ACL resection. No ACL-resection-associated changes in the mass of both muscles were observed 1 week after ACL resection. On the other hand, ACL-resection-associated reduction on mean fiber cross-sectional area (fiber CSA) in RF muscle lasted 48 weeks after ACL resection. Furthermore, ACL-resection associated increase in fiber composition of type I fiber in RF muscle in contralateral limbs. In addition, long-term effects of ACL resection were observed in both ACL-resected and contralateral limbs. Evidences from this study suggested that ACL resection may cause to change in the morphological (fiber CSA) and contractile (distribution of fiber types) properties of skeletal muscles around the knee joint in not only injured but also contralateral limb. Rehabilitation for quantitative and qualitative muscle changes by ACL resection may be required a special care for a long-term period.
Key words: Sports injury, ligament, quadriceps, hamstring, muscle fiber type, recovery


           Key Points
  • ACL-resection-associated effects on mean fiber CSA as well as the relative distribution of fiber types lasted 48 weeks after ACL resection were investigated.
  • The responses of fiber CSA and fiber type composition following ACL resection in RF muscle were different from SM muscle.
  • Long-term effects of ACL resection were observed on the not only ACL-resected but also contralateral limbs.
  • Rehabilitation for quantitative and qualitative muscle changes by ACL resection may be required a special care for a long-term period.
 
 
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